Rate and duration of net glycogen synthesis following glucose administration to fasted human leukocytes

When glucose was added to fasted human leukocytes in a final concentration of 0.5-5 mM there was a phase of glycogen synthesis followed by a phase of glycogen breakdown. The duration of the phase of net glycogen synthesis increased with increasing concentrations of glucose applied, but the net rate of glycogen synthesis was inversely related to this figure and decreased from approx. 7 nmol/10(7) cells per min at 0.5 mM glucose to an average of 4 nmol/10(7) cells per min at 5 mM glucose.