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Coagulation factor XIII: a useful polymorphic genetic marker.

J B Graham, C J Edgell, H Fleming

    Human Genetics
    |January 1, 1984
    PubMed
    Summary
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    Blood coagulation Factor XIII-A (FXIII-A) is inherited as an autosomal co-dominant trait. Its common variants were analyzed in Caucasian families and patients, showing FXIII-A is a useful genetic marker.

    Area of Science:

    • Genetics
    • Biochemistry

    Background:

    • Factor XIII-A (FXIII-A) is crucial for blood coagulation.
    • Understanding its genetic variants and inheritance patterns is important for genetic studies.

    Purpose of the Study:

    • To analyze the inheritance pattern of FXIII-A variants.
    • To determine the allelic frequencies of FXIII-A in different ethnic groups.
    • To assess FXIII-A as a genetic marker for linkage and paternity testing.

    Main Methods:

    • Agarose gel electrophoresis was used to separate FXIII-A variants in plasma samples.
    • Monodansyl cadaverine labeling visualized transglutaminase activity.
    • Segregation analysis and father-to-son transmission were employed.

    Main Results:

    Related Experiment Videos

    • FXIII-A was confirmed to be inherited as an autosomal co-dominant trait.
    • Allelic frequencies were F13A*1 = 0.82 and F13A*2 = 0.18 in a random sample.
    • Gene frequencies were similar across racial groups and in unrelated spouses.
    • Genetic equilibrium was observed in both study groups.

    Conclusions:

    • FXIII-A exhibits useful genetic marker properties due to its polymorphism and uniform gene frequencies.
    • FXIII-A is a valuable tool for linkage studies and paternity testing.
    • No linkage was found between FXIII-A and chromosome 6 markers BF and GLO.