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Aneurysmal bone cyst of the jaws. (II). Pathogenesis
International Journal of Oral Surgery
|April 1, 1984
Summary
Aneurysmal bone cysts may arise secondary to primary bone lesions like giant cell granulomas. Microcysts forming from edema in these lesions can lead to aneurysmal bone cyst development.
Area of Science:
- Bone pathology
- Skeletal oncology
- Histopathology
Background:
- The origin of aneurysmal bone cysts (ABCs) is debated.
- This study investigates if ABCs develop secondary to other bone conditions.
Purpose of the Study:
- To test the hypothesis that ABCs are secondary phenomena.
- To identify primary bone lesions that may precede ABC formation.
Main Methods:
- Histological examination of 303 bone lesions.
- Analysis for microcysts and blood-filled spaces characteristic of ABCs.
Main Results:
- Microcysts/blood spaces found in 28% of central giant cell granulomas.
- Similar features observed in fibrous dysplasia (10%), fibrosarcomas (14%), and osteosarcomas (11%).
- Paget's disease and ossifying/cementifying fibromas showed lower frequencies.
Conclusions:
- ABCs likely initiate from microcysts in primary lesions with loose stroma.
- Vessel rupture into microcysts leads to bone resorption and new bone formation.
- This process may explain rare malignant ABC presentations.