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Candida in patients with oral lichen planus
International Journal of Oral Surgery
|June 1, 1984
Summary
Yeasts, particularly Candida albicans, are frequently found in oral lichen planus (OLP) lesions. Treatment with amphotericin B significantly improved symptoms and clinical signs in OLP patients with yeast presence.
Area of Science:
- Oral pathology
- Mycology
- Dermatology
Background:
- Oral lichen planus (OLP) is a chronic inflammatory condition affecting oral mucosa.
- The role of microbial factors, specifically yeasts, in OLP pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the prevalence of yeasts in oral lichen planus (OLP) lesions.
- To compare yeast presence in OLP patients with a healthy control group.
- To evaluate the efficacy of antifungal treatment in OLP patients with positive yeast findings.
Main Methods:
- Cultivation and histological examination of yeast in oral lesions from 41 OLP patients and a control group.
- Recording of histological features of OLP.
- Treatment of 18 OLP patients with positive yeast findings using amphotericin B.
Main Results:
- Yeasts were detected in 46% of OLP patients, with moderate-heavy growth in 29% compared to 7% in controls.
- Candida albicans comprised over 80% of identified yeasts.
- Antifungal treatment resulted in subjective relief (89%) and clinical improvement (94%) in OLP patients.
- Yeast presence correlated significantly with low unstimulated salivary secretion rates.
Conclusions:
- Yeasts, predominantly Candida albicans, are common in OLP lesions and may play a role in the condition.
- Antifungal therapy is effective in managing OLP symptoms and signs when yeast is present.
- Salivary function may influence yeast colonization in OLP patients.