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Related Experiment Videos

Tail lesions in C3H/He mice.

J P Koopman, J T Van der Logt, J W Mullink

    Laboratory Animals
    |April 1, 1984
    PubMed
    Summary

    Stress-induced tail lesions in C3H/He mice were observed following transport. Investigations ruled out viral causes and transmission, indicating stress as the primary factor.

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    Area of Science:

    • Veterinary Pathology
    • Animal Models
    • Immunology

    Background:

    • C3H/He mice are a common inbred strain used in research.
    • Tail lesions can manifest in mice due to various etiological factors.
    • Understanding disease etiology in research animals is crucial for data integrity.

    Purpose of the Study:

    • To investigate the cause of tail lesions in C3H/He mice.
    • To differentiate between infectious and non-infectious causes of the observed syndrome.
    • To identify potential triggers for the development of skin lesions in laboratory mice.

    Main Methods:

    • Histopathological examination of affected tissues.
    • Serological surveys for common viral pathogens.
    • Transmission studies to assess infectivity.
    • Virus isolation attempts from skin lesions.

    Main Results:

    • Mice from different suppliers developed tail lesions post-arrival.
    • Histology did not reveal inclusion bodies.
    • Serological tests were negative for relevant viruses.
    • The condition was not transmissible to healthy mice.
    • No virus was cultured from skin lesions.

    Conclusions:

    • The observed tail lesions in C3H/He mice were not caused by infectious agents.
    • The syndrome is attributed to environmental stress, specifically transport.
    • Stress-induced conditions should be considered in the differential diagnosis of skin lesions in laboratory animals.

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