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Related Experiment Videos

Clathrin lattice reorganization: theoretical considerations.

M P Lisanti, M Flanagan, S Puszkin

    Journal of Theoretical Biology
    |May 7, 1984
    PubMed
    Summary

    Clathrin trimers form hexagonal lattices that transform into coated pits. A proposed mechanism explains this by removing trimers, initiating fringe transformations that lead to pentagons and lattice curvature.

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    Area of Science:

    • Cell Biology
    • Biophysics

    Background:

    • Clathrin-mediated endocytosis involves the formation of coated pits.
    • Clathrin lattices assemble from trimer units into polygonal structures.

    Purpose of the Study:

    • To postulate a mechanism for the transformation of flat hexagonal clathrin lattices into coated pits.
    • To explain the geometric basis for the formation of pentagons within clathrin lattices.

    Main Methods:

    • Utilized an established model for packing clathrin trimers into lattices.
    • Simulated the assembly process through single trimer additions and removals.
    • Analyzed geometric constraints on trimer elimination from polygonal sheets.

    Main Results:

    • Identified two primary modes of trimer removal: 'fringe transformation' (edge removal) and 'hub transformation' (center removal).
    • Demonstrated that 'fringe transformation' is geometrically favored and often precedes 'hub transformation'.
    • Showed that initial fringe transformations facilitate subsequent hub transformations, leading to pentagon formation and lattice curvature.

    Conclusions:

    • The geometry of hexagonal clathrin lattices dictates a specific transformation pathway initiating with fringe transformations.
    • This pathway explains observed intermediate structures and the eventual curvature of clathrin lattices during coated pit formation.
    • The proposed mechanism provides a geometric explanation for the transition from flat lattices to curved coated pits.

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