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Iohexol lumbar myelography: clinical study.

J C Holder, E F Binet, D K Kido

    AJNR. American Journal of Neuroradiology
    |July 1, 1984
    PubMed
    Summary
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    The new nonionic contrast medium, iohexol, demonstrated a favorable safety profile in lumbar myelography. This iohexol myelography resulted in fewer and less severe adverse reactions compared to previous agents.

    Area of Science:

    • Radiology
    • Neurology
    • Medical Imaging

    Background:

    • Water-soluble contrast agents for myelography have historically been associated with significant adverse effects.
    • Metrizamide, a previous agent, showed improvements but still presented notable side effects.

    Purpose of the Study:

    • To evaluate the safety and efficacy of the nonionic contrast medium iohexol in lumbar myelography.
    • To compare the adverse reaction profile of iohexol with that of metrizamide.

    Main Methods:

    • Forty-three patients underwent lumbar myelography utilizing iohexol.
    • Comprehensive laboratory tests, neurological examinations, and electrocardiograms were performed.
    • Adverse reactions and radiographic visualization quality were assessed.

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    Main Results:

    • No significant alterations were observed in laboratory tests, neurological examinations, or electrocardiograms.
    • Mild electroencephalographic changes occurred in one patient.
    • 13 patients (30%) experienced 19 adverse reactions, with only one severe reaction; no neuropsychologic events like seizures or hallucinations were reported.

    Conclusions:

    • Iohexol myelography is associated with a significantly reduced incidence and severity of adverse reactions compared to metrizamide.
    • The radiographic visualization with iohexol is comparable to metrizamide.
    • Iohexol offers an improved safety profile, minimizing disturbing neuropsychologic reactions in myelography.