Effects of valproic acid derivatives on the acquisition of active avoidance behavior in the rat

The effects of valproic acid derivatives on the acquisition of active avoidance behavior have been studied in the rat. Sodium valproate (50 and 100 mg/kg), magnesium valproate (100 mg/kg) and dipropylacetamide (100 mg/kg) were administered intraperitoneally 1 hr prior to the behavioral test (shuttle-box, single session). Acquisition of active avoidance behavior was facilitated by sodium valproate, unaffected by magnesium valproate, and inhibited by dipropylacetamide. These findings suggest that behavioral effects of valproic acid derivatives cannot be explained only in terms of a general inhibitory action on the central nervous system.