Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metabolic activity of developing rabbit lung.

M Hamosh, Y Shechter, P Hamosh

    Pediatric Research
    |February 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Insulin-like effects of tungstate and molybdate: mediation through insulin receptor independent pathways.

    Endocrine·2010
    Same author

    Lactogenic hormones rapidly activate p21( ras )/mitogen-activated protein kinase in Nb2-11C rat lymphoma cells.

    Endocrine·2010
    Same author

    Engineering prolonged-acting prodrugs employing an albumin-binding probe that undergoes slow hydrolysis at physiological conditions.

    Journal of controlled release : official journal of the Controlled Release Society·2009
    Same author

    Reversible pegylation of insulin facilitates its prolonged action in vivo.

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2008
    Same author

    Structural and functional aspects of three major glycoproteins of the human milk fat globule membrane.

    Advances in experimental medicine and biology·2002
    Same author

    Overview: conditionally essential nutrients: can long-chain polyunsaturated fatty acids and nucleotides qualify?

    Advances in experimental medicine and biology·2002
    Same journal

    Neurologic sequelae of cerebral malaria and other forms of severe malaria in children.

    Pediatric research·2026
    Same journal

    Home and in-hospital phototherapy as comparable select routine approach for neonatal hyperbilirubinemia.

    Pediatric research·2026
    Same journal

    Polycyclic aromatic hydrocarbons and perinatal outcomes: a scoping review.

    Pediatric research·2026
    Same journal

    Interindividual variability in metformin pharmacokinetics in pediatric patients.

    Pediatric research·2026
    Same journal

    Comparison of Crohn's disease exclusion diet and exclusive enteral nutrition in prospectively followed paediatric patients with Crohn's disease.

    Pediatric research·2026
    Same journal

    Natural Language Processing (NLP) tools are superior to ICD-10 codes in capturing clinically relevant information.

    Pediatric research·2026
    See all related articles

    Lung metabolism in rabbits shows significant developmental changes, particularly in protein and lipid synthesis. Fetal and newborn lungs exhibit higher glucose utilization and lipid biosynthesis compared to older rabbits.

    Area of Science:

    • Developmental Biology
    • Pulmonary Metabolism
    • Biochemistry

    Background:

    • Lung development involves dynamic metabolic shifts.
    • Understanding perinatal lung metabolism is crucial for assessing respiratory health.
    • Rabbit models offer insights into mammalian lung maturation.

    Purpose of the Study:

    • To investigate the developmental changes in rabbit lung metabolism from the perinatal period through adulthood.
    • To characterize the uptake and utilization of key metabolic substrates (leucine, glucose, palmitate) across different age groups.
    • To compare metabolic pathways, including protein synthesis and lipid biosynthesis, between fetal/neonatal and juvenile/adult rabbit lungs.

    Main Methods:

    • Utilized radiolabeled tracers ([3H]leucine, [U-14C]glucose, [3H]palmitate) to quantify substrate uptake and incorporation.

    Related Experiment Videos

  • Studied lung tissue from rabbits at various developmental stages: fetal, newborn, 7, 28, 90 days, and 1-1.5 years.
  • Measured leucine incorporation into protein, palmitate incorporation into lipids, and glucose uptake/lactate production.
  • Analyzed the fate of glucose carbon in lipid biosynthesis, distinguishing between fatty acid and glycerol incorporation.

    • Main Results:

    • Leucine incorporation into lung protein was highest in fetal and newborn rabbits, declining rapidly postnatally.
    • Palmitate incorporation decreased in the first postnatal week, then increased and stabilized in older rabbits.
    • Fetal rabbit lungs showed higher glucose uptake and lactate production compared to all other age groups.
    • Lipid biosynthesis from glucose was significantly higher in fetal lungs, with a distinct preference for fatty acid synthesis over glycerol synthesis, unlike in older rabbits.

    Conclusions:

    • Rabbit lung metabolism undergoes substantial changes during development, with distinct patterns in the perinatal period.
    • Protein and lipid metabolism pathways differ significantly between early development and later life stages.
    • These findings highlight the unique metabolic requirements of the developing lung, particularly during the transition from fetal to postnatal life.