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Related Experiment Videos

Acute cholecystitis and thiazides.

W Van der Linden, B Ritter, G Edlund

    British Medical Journal (Clinical Research Ed.)
    |September 15, 1984
    PubMed
    Summary

    Thiazide diuretic use was associated with a doubled risk of acute cholecystitis, a gallbladder inflammation. This suggests thiazides may trigger acute gallbladder attacks in individuals with gallstones.

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    Area of Science:

    • Pharmacovigilance
    • Gastroenterology
    • Epidemiology

    Background:

    • Acute cholecystitis is a common cause of hospital admission.
    • Gallstones are a primary risk factor for acute cholecystitis.
    • The role of medications in acute cholecystitis development requires further investigation.

    Purpose of the Study:

    • To investigate the association between thiazide diuretic use and the risk of developing acute cholecystitis.
    • To determine if thiazide use increases the likelihood of acute gallbladder inflammation.

    Main Methods:

    • A population-based case-control study was conducted in Jämtland county, Sweden.
    • Drug purchases of 17,000 individuals were monitored.
    • Patients with acute cholecystitis were compared with age- and sex-matched controls regarding thiazide purchase history.

    Main Results:

    • Patients with acute cholecystitis were more likely to have purchased thiazides in the year prior to admission (relative risk = 2.1, 95% CI 1.1-3.9).
    • This association suggests thiazides may precipitate acute cholecystitis in patients with pre-existing gallstones.

    Conclusions:

    • Thiazide diuretic use is associated with an increased risk of acute cholecystitis.
    • The findings suggest a potential mechanism where thiazides may trigger acute gallbladder inflammation in individuals with gallstones.

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