Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

A calculator program for individualizing factor VIII dosage.

G Longo, M Matucci, M Morfini

Drug Intelligence & Clinical Pharmacy

|September 1, 1984

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

AFM Force Volume for Extracellular Vesicle Detection and Membrane Blebbing Analysis Through Mechanical Signature Mapping.

Journal of molecular recognition : JMR·2026

Same author

Complex abdomen: a scoping review.

Hernia : the journal of hernias and abdominal wall surgery·2025

Same author

Search for Dark-Matter-Nucleon Interactions via Migdal Effect with DarkSide-50.

Physical review letters·2023

Same author

Search for Dark Matter Particle Interactions with Electron Final States with DarkSide-50.

Physical review letters·2023

Same author

Treatments for relapsed-refractory diffuse large B-cell lymphoma: comparison of overall survival outcomes observed with four novel agents.

European review for medical and pharmacological sciences·2022

Same author

First Direct Detection Constraints on Planck-Scale Mass Dark Matter with Multiple-Scatter Signatures Using the DEAP-3600 Detector.

Physical review letters·2022

Same journal

Profile of prescription medication in a pediatric population.

Drug intelligence & clinical pharmacy·1988

Same journal

SI units in drug therapeutics.

Drug intelligence & clinical pharmacy·1988

Same journal

Physicians' review of significant interventions by clinical pharmacists in inpatient care.

Drug intelligence & clinical pharmacy·1988

Same journal

Possible interaction of ranitidine with phenytoin.

Drug intelligence & clinical pharmacy·1988

Same journal

Famotidine-associated mental confusion in elderly patients.

Drug intelligence & clinical pharmacy·1988

Same journal

Intravenous self-administration of elemental mercury: efficacy of dimercaprol therapy.

Drug intelligence & clinical pharmacy·1988

See all related articles

A new calculator program individualizes Factor VIII dosage using patient data and the Sawchuk and Zaske method. This approach accurately predicts Factor VIII levels for hemophilia treatment.

Area of Science:

Pharmacokinetics
Biotechnology
Medical Informatics

Background:

Factor VIII is crucial for treating classic hemophilia.
Individualizing Factor VIII dosage is essential for effective treatment.
Existing methods may lack precision for personalized dosing.

Purpose of the Study:

To develop a calculator program for individualized Factor VIII dosage.
To implement the Sawchuk and Zaske method for parameter estimation.
To validate the program's accuracy in hemophilia patients.

Main Methods:

Developed a calculator program for Hewlett-Packard 41-CV.
Utilized the 1977 Sawchuk and Zaske method.
Employed nonlinear iterative least-squares (modified Gauss-Newton) for parameter estimation.

Related Experiment Videos

Tested the program in three classic hemophilia patients.

Main Results:

Individual kinetic parameters were estimated from test-dose data.
Predicted concentration-time curves showed good agreement with measured levels.
The program demonstrated accuracy in multiple-dose treatment scenarios.

Conclusions:

The developed calculator program effectively individualizes Factor VIII dosage.
Accurate pharmacokinetic parameter estimation is key to predicting drug levels.
This tool aids in optimizing Factor VIII therapy for hemophilia patients.