Related Experiment Videos
IgA polymorphism in mice: individual light chains can pair covalently with some alpha heavy chains and non-covalently
The molecular basis for the two different forms of IgA in mice, distinguished by the covalent or non-covalent association of light (L) and heavy (H) chains, is unknown. In this communication, we show, using somatic cell hybridization to construct cells producing new combinations of alpha and L chains, that individual L chains probably can pair both covalently and non-covalently depending on the alpha chain.
The molecular basis for the two different forms of IgA in mice, distinguished by the covalent or non-covalent association of light (L) and heavy (H) chains, is unknown. In this communication, we show, using somatic cell hybridization to construct cells producing new combinations of alpha and L chains, that individual L chains probably can pair both covalently and non-covalently depending on the alpha chain.