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[Pharmacological studies on new cephamycin, MT-141. (1) Its effect on central nervous system, respiration and
Abstract:
The results on pharmacological effects of MT-141 were as follows. MT-141 did not exert effect on central nervous system in mice and rabbits but potentiated the anesthetic effect of thiopental at doses above 800 mg/kg i.v. MT-141 slightly raised a level of blood pressure in dogs and also caused a slight increase in the blood flow and heart rate when intravenously given more than 400 mg/kg. This compound did not affect the spontaneous contraction of isolated guinea pig atria and the blood vessels in perfused rabbit ears. MT-141 did not significantly affect the spontaneous contraction and coronary flow in isolated hearts of guinea pig. The body temperature was raised slightly by an injection of more than 400 mg/kg of MT-141. These results suggest that MT-141 does not possess specific effect on central nervous system but at a high dose slightly affects the autonomic nervous system such as blood pressure, body temperature, heart rate and blood flow in experimental animals.
Insights
MT-141 (a novel compound) did not impact the central nervous system in animal models. However, at high doses, it slightly affected autonomic functions like blood pressure and heart rate.
Area of Science:
- Pharmacology
- Neuroscience
- Autonomic Nervous System Research
Context:
- Investigating the pharmacological profile of novel compounds is crucial for understanding their potential therapeutic applications and safety.
- The autonomic nervous system regulates involuntary bodily functions, and its modulation by external agents requires careful study.
Purpose:
- To elucidate the pharmacological effects of MT-141 on the central and autonomic nervous systems in various experimental animal models.
- To determine the dose-dependent effects of MT-141 on physiological parameters including central nervous system activity, blood pressure, heart rate, and body temperature.
Summary:
- MT-141 demonstrated no significant effects on the central nervous system in mice and rabbits.
- Intravenous administration of MT-141 at doses exceeding 400 mg/kg in dogs resulted in slight elevations in blood pressure, heart rate, and blood flow.
- Higher doses of MT-141 (above 800 mg/kg i.v.) potentiated the anesthetic effects of thiopental in mice and rabbits.
- MT-141 did not affect the spontaneous contractions of isolated guinea pig atria or blood vessels in perfused rabbit ears.
- The compound caused a slight increase in body temperature when injected at doses over 400 mg/kg.
- MT-141 did not significantly alter spontaneous contraction or coronary flow in isolated guinea pig hearts.
Impact:
- These findings suggest MT-141 lacks specific central nervous system activity.
- The study indicates that MT-141 may exert mild effects on the autonomic nervous system at high concentrations.
- Understanding these effects is vital for assessing the safety and potential applications of MT-141 in preclinical research.