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[Immunostimulation in an animal model using intestinal bacteria preparations]
Die Nahrung
|January 1, 1984
Summary
Injecting killed E. coli boosted mice’s immune defense against Salmonella typhimurium. Oral vaccines also increased resistance, possibly by enhancing immune cell function.
Area of Science:
- Immunology
- Microbiology
- Infectious Diseases
Background:
- Non-specific immune responses can enhance resistance to infections.
- Intestinal bacteria play a role in modulating host immunity.
Purpose of the Study:
- To investigate the immunomodulatory effects of bacterial preparations on host resistance.
- To determine the efficacy of different vaccines against bacterial infections.
Main Methods:
- Mice were treated with injectable killed E. coli or oral vaccines (Streptococcus faecalis and E. coli, viable S. faecalis, viable E. coli).
- Subsequent challenge infections with Salmonella typhimurium and Haemophilus influenzae were performed.
- Microbicidal activity, leukocyte activity, and neutrophilic cell chemotaxis were assessed.
Main Results:
- Injectable killed E. coli increased blood microbicidal activity and protection against S. typhimurium.
- Oral vaccines enhanced resistance to S. typhimurium and H. influenzae.
- Enhanced resistance was linked to increased chemotactic efficiency of neutrophilic cells.
Conclusions:
- Bacterial preparations, both injectable and oral, can non-specifically enhance host resistance to infections.
- The mechanism involves improved immune cell function, particularly neutrophilic chemotaxis.
- Further research is needed to elucidate the action of all tested oral vaccines.