Differential improvements from haloperidol in two types of schizophrenics

Two types of schizophrenic patients, 27 with a high and 21 with a low energetic level, were treated for 3 weeks under double blind conditions with 16 (24 patients) or 80 mg (24 patients) haloperidol orally per day. The patients were rated by the ward psychiatrist as markedly or not markedly improved. Evaluation made by odds ratio comparison showed that (1) patients with a high energetic level (plus-type patients) improved with low doses whereas (2) patients with a low energetic level (minus-type patients) improved with high doses of haloperidol.