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Lung function tests in connective tissue diseases associated with Raynaud's phenomenon
Respiration; International Review of Thoracic Diseases
|January 1, 1984
Summary
Patients with Raynaud's phenomenon and connective tissue diseases often show increased dead space ventilation, indicating pulmonary blood flow redistribution. Lung function tests reveal uneven air distribution and small airway disease.
Area of Science:
- Pulmonary Medicine
- Rheumatology
- Cardiovascular Physiology
Background:
- Raynaud's phenomenon is associated with connective tissue diseases.
- Pulmonary complications can occur in these patients.
- The impact on lung function requires further investigation.
Purpose of the Study:
- To investigate pulmonary function alterations in patients with connective tissue diseases and Raynaud's phenomenon.
- To determine if pulmonary circulation spasm occurs in these patients.
Main Methods:
- Pulmonary physiologic techniques were employed.
- 13 patients with connective tissue diseases and Raynaud's phenomenon were studied.
Main Results:
- Increased dead space ventilation with normal tidal volume was common, suggesting pulmonary blood flow redistribution due to vascular spasm.
- Uneven distribution of inspired air, reduced diffusing capacity, and decreased dynamic compliance with increasing respiratory rate indicated small airway disease.
- Restrictive or obstructive defects, reduced lung compliance, and hypoxemia were less common, likely in advanced disease stages.
Conclusions:
- Pulmonary vascular spasm and small airway disease are significant findings in connective tissue diseases associated with Raynaud's phenomenon.
- These pulmonary alterations may precede more advanced lung dysfunction.
- Pulmonary function testing is crucial for early detection and management.