[Functional state of the thyroid and its regulatory system in tumor-bearing animals]

A comparative study of labelled thyroxine and iodine accumulation was carried out in the thyroid endocrine complex under endoliquor and intraabdominal introduction of thyrotropic hormone (TTH) and thyrotropin-releasing-factor (TRF) in rats with transplantable and induced tumours as well as in intact animals. A sharp decrease of the system response to TRF in tumour-bearing animals was established. The incorporation of labelled thyroxine introduced into the thyroid gland tissue and posterior region of the hypothalamus is found to be lower under the tumour growth. The character of changes causing the disturbances in the activity of the thyroid gland should be taken into account in an attempt to normalize the gland activity. The normalization should be based on the complex influence directed to all the links of the hypothalamus-pituitary thyroid gland system.