[Influence of lithium carbonate on the effects of the natriuretic factor]

It has been shown in rat experiments that administration of lithium carbonate for 3 days (100 mg/kg) enhances renal excretion of water and electrolytes following an increase in the volume of extracellular fluid. In this case renal excretion of natriuretic factor rises, whereas its concentration in blood plasma does not ascend. Lithium carbonate raises the sensitivity of the kidneys to natriuretic factor and reduces its effect on transport activity in the small intestine.