Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Implanted material tolerance studies for a multiple-channel cochlear prosthesis.

R K Shepherd, R L Webb, G M Clark

    Acta Oto-Laryngologica. Supplementum
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparison of electrode position in the human cochlea using various perimodiolar electrode arrays.

    The American journal of otology·2000
    Same author

    Effects of hypesthesia on oral behaviors of the orthognathic surgery patient.

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons·1998
    Same author

    Histological and physiological effects of the central auditory prosthesis: surface versus penetrating electrodes.

    Hearing research·1998
    Same author

    Comparison of current waveforms for the electrical stimulation of residual low frequency hearing.

    Acta oto-laryngologica·1998
    Same author

    Variability of amplitude and area of the auditory nerve compound action potential.

    Acta oto-laryngologica·1998
    Same author

    Changes in synthetic and natural vowel perception after specific training for congenitally deafened patients using a multichannel cochlear implant.

    Ear and hearing·1998
    Same journal

    Towards a consensus on a hearing preservation classification system.

    Acta oto-laryngologica. Supplementum·2013
    Same journal

    Inner ear drug delivery system from the clinical point of view.

    Acta oto-laryngologica. Supplementum·2010
    Same journal

    Hydrogen protects vestibular hair cells from free radicals.

    Acta oto-laryngologica. Supplementum·2010
    Same journal

    Distribution of bone marrow-derived cells in the vestibular end organs and the endolymphatic sac.

    Acta oto-laryngologica. Supplementum·2010
    Same journal

    Impacts and limitations of medialization thyroplasty on swallowing function of patients with unilateral vocal fold paralysis.

    Acta oto-laryngologica. Supplementum·2010
    Same journal

    A tissue-engineering approach for stenosis of the trachea and/or cricoid.

    Acta oto-laryngologica. Supplementum·2010
    See all related articles

    Intracochlear electrode implantation and chronic electrical stimulation show minimal histopathological effects on the cochlea. Long-term electrical stimulation does not harm auditory neurons, but labyrinthine infection significantly reduces spiral ganglion cells.

    Area of Science:

    • Otoacoustic Emissions
    • Neuroscience
    • Biomaterials

    Background:

    • Cochlear implants are crucial for hearing restoration.
    • Understanding the histopathological effects of cochlear implants is vital for patient safety and device efficacy.
    • Previous studies have raised concerns about tissue damage and device degradation.

    Purpose of the Study:

    • To evaluate the histopathological effects of intracochlear electrode implantation.
    • To assess the impact of chronic electrical stimulation on cochlear tissues and neural structures.
    • To investigate the biocompatibility of electrode array materials and the potential for infection spread.

    Main Methods:

    • Temporal bone studies and animal models were utilized.
    • Histopathological analysis examined tissue reactions and cell viability.

    Related Experiment Videos

  • Long-term electrical stimulation with controlled biphasic pulses was applied.
  • Infection models were used to evaluate protective measures.

    • Main Results:

    • Electrode insertion caused minimal damage to the membranous labyrinth.
    • Implanted materials elicited only mild tissue reactions.
    • Chronic electrical stimulation (500-2000 hours) did not affect auditory neuron population or activity.
    • Labyrinthine infection severely reduced spiral ganglion cells, but a fibrous seal prevented infection spread.
    • No bone growth was associated with electrical stimulation, and electrode materials showed minimal degradation.

    Conclusions:

    • Intracochlear electrode implantation and chronic electrical stimulation are generally safe with minimal histopathological impact.
    • Protecting the cochlea from infection is critical for preserving spiral ganglion cells.
    • The materials used in current cochlear electrode arrays demonstrate good biocompatibility and long-term stability.