Related Experiment Video

Updated: Aug 9, 2026

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
05:57

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

Delayed diagnosis of duodenal obstruction in Down syndrome

G V Smith, R L Teele

    AJR. American Journal of Roentgenology
    |May 1, 1980
    PubMed

    Insights

    Children with Down syndrome (trisomy 21) can develop congenital duodenal stenosis, a serious upper gastrointestinal obstruction. Early diagnosis through radiographic evaluation is crucial for timely intervention in these pediatric patients.

    Area of Science:

    • Pediatric Gastroenterology
    • Clinical Genetics
    • Medical Imaging

    Background:

    • Down syndrome (trisomy 21) is a genetic disorder associated with various congenital anomalies.
    • Upper gastrointestinal obstruction is a potential complication in children with Down syndrome.

    Observation:

    • Four children with Down syndrome presented in late childhood with symptoms of upper gastrointestinal tract obstruction.
    • Radiographic evaluation was performed for each patient.

    Findings:

    • The diagnostic criteria included Down syndrome, retained foreign material in the stomach or proximal duodenum, and evidence of obstruction.
    • Congenital duodenal stenosis was diagnosed in all four patients.

    Implications:

    • This highlights a specific gastrointestinal complication in children with Down syndrome.
    • Emphasizes the importance of considering congenital duodenal stenosis in the differential diagnosis of gastrointestinal obstruction in this population.
    • Suggests the need for vigilant monitoring and diagnostic workup for gastrointestinal issues in children with Down syndrome.

    More Related Videos

    Modified Single-Loop Reconstruction for Pancreaticoduodenectomy13:01

    Modified Single-Loop Reconstruction for Pancreaticoduodenectomy

    Published on: September 28, 2019

    Robotic D3 Partial Duodenal Resection with Primary Side-to-Side Anastomosis10:41

    Robotic D3 Partial Duodenal Resection with Primary Side-to-Side Anastomosis

    Published on: December 15, 2023

    Related Concept Videos

    Esophageal Strictures-II: Clinical Features and Management01:26

    Esophageal Strictures-II: Clinical Features and Management

    Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
    Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
    Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

    Endoscopic Procedures I: Esophagogastroduodenoscopy

    An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
    During an EGD, the endoscope can be used to:
    Upper GI Series: Barium Swallow01:24

    Upper GI Series: Barium Swallow

    The Barium Swallow Study, or a Barium Esophagogram, is a diagnostic imaging method used to visualize the upper gastrointestinal (GI) tract, including the esophagus, stomach, and small intestine. It employs barium sulfate, a radiopaque contrast material, to provide clear images of the upper digestive system, helping to identify abnormalities, diseases, or structural issues.
    Purpose and Procedure
    Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
    Pyloric Obstruction01:11

    Pyloric Obstruction

    Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
    Intestinal Obstruction I: Introduction01:29

    Intestinal Obstruction I: Introduction

    Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
    Intestinal Obstruction II: Pathophysiology01:07

    Intestinal Obstruction II: Pathophysiology

    Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...