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Pediatric sepsis cases significantly increased from 10% to 23.3% in child mortality over 15 years. This analysis highlights key findings in infant sepsis, emphasizing risk factors and differential diagnoses for better child survival.
Area of Science:
- Pediatrics
- Pathology
- Neonatal Medicine
Context:
- Analysis of pediatric autopsy material spanning 15 years (1963-1978).
- Observed trends in child mortality structure.
- Focus on the increasing prevalence of sepsis in infants.
Purpose:
- To analyze the changing incidence of sepsis in pediatric mortality.
- To identify common sites of infection and associated conditions.
- To emphasize the importance of differentiating sepsis from other neonatal conditions.
Summary:
- Sepsis rose from 10.0% to 23.3% of pediatric deaths.
- Primary infection focus often in cord arteries.
- Septicemia in infants under 3 months frequently co-occurs with ulcerative enterocolitis and unfavorable backgrounds like fetopathy, congenital malformations, and birth trauma.
Impact:
- Highlights the growing burden of pediatric sepsis.
- Underscores the need for early and accurate diagnosis in neonates.
- Informs clinical practice regarding differential diagnosis of neonatal sepsis.
Abstract:
An analysis of pediatric autopsy material for 15 years (1963--1978) revealed an increase in the percentage of sepsis in the general structure of child mortality from 10.0% to 23.3%. The primary focus is most frequently localized in the cord arteries. In infants of the first 3 months of age septicemia, frequently accompanied by ulcerative enterocolitis is more prevalent. Many infants have unfavourable backgrounds such as fetopathy, congenital malformations, birth traumas. Sepsis should be differentiated from congenital cytomegaly, adrenogenital syndrome, mucoviscidosis, intestinal infections with long duration, and sepsis with the hemolytic syndrom from hemolytic disease of neonates.