[Genetic, biochemical and functional study of the H-Y antigen in man]

H-Y antigen, first described as a male minor transplantation antigen, is unvarying associated with testicular differentiation, more than the presence of Y chromosome. The weak reactivity of anti H-Y serum needs quantitative and very sensitive tests to detect presence or absence of H-Y. This antigen may act as an hormone, to induce testicular differentiation of target cells, bearing a specific receptor at their surface. The relationship between an H-Y molecule immunologically defined by its antigenicity and H-Y factor defined by its function to induce testicular organogenesis must be determined.