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Peripheral circulation during sufentanyl and morphine anesthesia.

P Berthelsen, J Eriksen, N C Ahn

    Acta Anaesthesiologica Scandinavica
    |June 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    Sufentanyl anesthesia did not negatively impact peripheral circulation in dogs, unlike high-dose morphine which caused severe circulatory issues. This suggests sufentanyl is a safer anesthetic option for peripheral perfusion.

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Cardiovascular Physiology

    Background:

    • Sufentanyl is a potent, short-acting opioid anesthetic.
    • Limited independent research exists on sufentanyl's effects on peripheral circulation.
    • Morphine is known to affect hemodynamics, but its impact on microcirculation requires further investigation.

    Purpose of the Study:

    • To compare the effects of sufentanyl and morphine on peripheral perfusion in a canine model.
    • To evaluate the impact of beta-blockade on peripheral perfusion during sufentanyl and morphine anesthesia.
    • To assess the safety and efficacy of sufentanyl as an anesthetic agent concerning peripheral circulation.

    Main Methods:

    • Continuous monitoring of skeletal muscle surface pH (m-pH) as an index of microcirculation.

    Related Experiment Videos

  • Measurement of arterial and mixed venous blood gases and acid-base status.
  • Analysis of hematocrit, plasma electrolytes, and plasma proteins to calculate fluid shifts.

    • Main Results:

    • Sufentanyl (0.01 mg/kg) demonstrated no adverse effects on peripheral perfusion.
    • Morphine (4 mg/kg) induced a significant and rapid decrease in m-pH (7.29 to 7.11) and a 20% reduction in blood volume.
    • Beta-blockade with propranolol did not alter peripheral perfusion during either anesthetic.

    Conclusions:

    • Sufentanyl appears to be a safe anesthetic with no detrimental effects on peripheral circulation.
    • High-dose morphine anesthesia can lead to hypovolemic deterioration of circulation, likely due to histamine release.
    • Further human studies on sufentanyl are recommended, while high-dose morphine use should be reconsidered.