Effects of fominoben-HCl on rat liver

The effect of Fominoben-HCl (Noleptan) was studied in male rats given 200 mg/kg/day over one, two or four weeks. In all three experiments a slight enlargement of the liver was observed. After one-week treatment, activity of microsomal mixed-function oxidase was stimulated without an increase in cytochrome P-450 content. After 2 or 4 weeks of treatment the activity of microsomal mixed-function oxidase expressed as the activity per microsomal protein remained unchanged. The fominoben-HCl-caused biochemical changes and the slight increase in organ weight of the liver were completely reversible within 2 weeks after cessation of treatment.