Interaction of parachlorophenylalanine, mianserine and danitracen with amphetamine

Three antiserotonin compounds, p-chlorphenylalanine, mianserine and danitracen, were investigated for their influence on amphetamine stereotypy in correlation with concentration of this amine in blood serum and brain tissue. A positive correlation (decrease of stereotypy as well as the concentration of amphetamine in serum and brain) was found only for danitracen. p-Chlorphenylalanine and mianserine premedication decreased serum and brain tissue concentration of amphetamine, but enhanced amphetamine stereotypy effect. It is assumed that in the mixed pharmacodynamic-pharmacokinetic interaction in the case of mianserine and p-chlorphenylalanine the pharmacodynamic component (inhibition of the serotoninergic system in CNS) prevails, whereas in the case of danitracen the pharmacokinetic effect was superior.