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Regulation by complementary idiotypes. Ig protects the clone producing it.

D A Rowley, P Griffith, I Lorbach

    The Journal of Experimental Medicine
    |June 1, 1981
    PubMed
    Summary
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    Mice producing anti-idiotypic antibodies against phosphorylcholine (PC) showed suppressed immune responses. Passively administered antibodies protected stem cells, suggesting secreted antibodies may shield their producing clones.

    Area of Science:

    • Immunology
    • Antibody Structure and Function

    Background:

    • Mice producing anti-idiotypic antibodies against phosphorylcholine (PC) exhibit profound, long-lasting suppression of their PC response.
    • B cells from unresponsive mice are unresponsive in vitro, and suppressor cells were not identified.

    Purpose of the Study:

    • To investigate the mechanism of immune suppression induced by anti-idiotypic antibodies against phosphorylcholine.
    • To determine the role of complementary antibodies and passive antibody administration in modulating this suppression.

    Main Methods:

    • Induction of anti-idiotypic antibody production in A/He mice.
    • In vitro assessment of B cell responsiveness.
    • Administration of passive anti-PC antibody and sublethal irradiation to suppressed mice.

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    Main Results:

    • Suppression was initiated by anti-idiotypic antibody and prevented by complementary anti-PC antibody.
    • Sublethal irradiation and passive anti-PC antibody could rescue the suppressed response.
    • Recovery was slow, suggesting protection of stem cells by passively administered antibody.

    Conclusions:

    • Secreted immunoglobulins (Ig) may protect the B cell clone that produces them from tolerization.
    • Anti-idiotypic antibody responses can lead to profound and persistent immune suppression.
    • Stem cell protection by antibodies is a potential mechanism for immune recovery.