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Acne vulgaris: therapy directed at pathophysiologic defects.

S Ayres, R Mihan

    Cutis
    |July 1, 1981
    PubMed
    Summary

    This study presents a novel acne vulgaris treatment using vitamins A and E to correct keratinization defects, preventing acne lesions and inflammation without antibiotics.

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    Area of Science:

    • Dermatology
    • Biochemistry

    Background:

    • Acne vulgaris is a common skin condition characterized by inflammation and lesions.
    • Current treatments often involve antibiotics, raising concerns about resistance.
    • Abnormal keratinization of sebaceous follicles and lipid peroxidation contribute to acne pathogenesis.

    Purpose of the Study:

    • To present an effective therapeutic regimen for acne vulgaris.
    • To investigate the role of vitamins A and E in managing acne.
    • To offer an antibiotic-free treatment approach for acne.

    Main Methods:

    • A therapeutic regimen focusing on correcting keratinization defects with vitamins A and E was implemented.
    • The regimen aimed to prevent the formation of milia and comedones.
    • The study examined 98 consecutive cases of acne vulgaris.

    Main Results:

    • The vitamin A and E regimen effectively prevented milia and comedones.
    • This approach deprived Propionibacterium acnes of a suitable growth medium.
    • Vitamin E mitigated lipid peroxidation of sebum, reducing inflammatory aspects of acne.

    Conclusions:

    • Vitamins A and E offer an effective, antibiotic-free treatment for acne vulgaris.
    • Correcting keratinization defects is a key strategy in acne management.
    • This regimen addresses both the formation of lesions and inflammation.

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