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Peritoneal washing therapy for pseudomyxoma peritonei.
Southern Medical Journal
|August 1, 1981
Summary
Peritoneal washing therapy (PWT) using dextrose in water reduced abdominal girth in two patients with pseudomyxoma peritonei. One patient remains stable over 112 weeks, suggesting PWT is a safe ambulatory treatment.
Area of Science:
- Oncology
- Gastroenterology
- Nephrology
Background:
- Pseudomyxoma peritonei (PP) is a rare condition characterized by mucinous ascites.
- Current treatment options for PP have limitations.
- Exploring novel therapeutic approaches is crucial for improving patient outcomes.
Observation:
- Two patients diagnosed with pseudomyxoma peritonei underwent repeated intraperitoneal washing with 5% dextrose in water.
- Both patients exhibited a reduction in abdominal girth following the therapy.
- The second patient achieved long-term remission, remaining asymptomatic for over 112 weeks.
Findings:
- Peritoneal washing therapy (PWT) demonstrated efficacy in managing symptoms of pseudomyxoma peritonei.
- Biochemical analysis revealed excretion of acid mucopolysaccharides in urine post-PWT, indicating systemic absorption.
- The procedure was observed to be a safe ambulatory therapy.
Implications:
- PWT shows promise as a safe and effective treatment for pseudomyxoma peritonei.
- Further research is warranted to elucidate the long-term effects on renal function.
- This therapeutic approach may offer a viable option for patients with advanced disease.