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[Effect of anions on the oxidative phosphorylation and ATPase activity in mitochondria]
Abstract:
Bicarbonate, sulfate and thiocyanate affected distinctly the ADP/O ratio and the rate of oxygen consumption in liver mitochondria. Alterations in the ADP/O coefficient and the ATPase activity were studied in liver and heart mitochondria of control and fasted rats as well as of animals maintained under hypoxy-hypercapnic conditions. Satisfactory correlation was shown between a decrease both in the ADP/O ratio and in sensitivity of ATPase to bicarbonate in liver mitochondria of the animals subjected to these treatments.