[Morphochemical changes in the brain in experimental hypothyroidism]

Under conditions of experimentally induced thyroid insufficiency a number of structural changes were revealed in the brain tissues and the pia mater. Of a particular importance among them were changes in the vessels of the microcirculation system that manifested themselves in the form of disturbed metabolism of acidic mucopolysaccharides with their accumulation and polymerization in the course of hypothyroidism, as well as accumulation of biogenic monoamines (noradrenaline and serotonin) in the endothelium of the precapillary arterioles and capillaries. The changes discovered may be taken as a basis for the explanation of some neurological and especially vascular manifestations on the part of the nervous system in patients with hypothyroidism.