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[Pathomorphological changes in the kidneys in experimental hypothyroidism]
Abstract:
Morphohistochemical changes were studied in the kidneys of rats in experimental hypothyroidism. The latter was induced by subtotal thyroidectomy (observation periods--60 days), feeding of 6-methylthiouracil (observation periods--100 days), feeding of 6-methylthiouracil to thyroidectomized animals (observation periods--7 to 60 days). Animals of all the three groups displayed morphohistochemical signs of disturbance of acid and neutral polysaccharide metabolism in the vaso-stromal structures of the kidneys and also in the glomeruli. The degree of these changes depended directly on the extent and the duration of a hypothyroid condition. The changes described led to development of sclerosis. Among these changes attention was attracted to deposition of calcium salts in the epithelium, chiefly of the distal tubules.
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