Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T-cell function in chronic lymphocytic leukaemia.

C A Whelan, R Willoughby, S R McCann

    British Journal of Haematology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Quality of life: why most doctors don't care?

    QJM : monthly journal of the Association of Physicians·2018
    Same author

    Abstracts of the proceedings of the 20th annual meeting of the irish neurological association held on 25th-26th may, 1984.

    Irish journal of medical science·2016
    Same author

    Immunoglobulin levels and auto-antibodies in normal healthy adults.

    Irish journal of medical science·2016
    Same author

    Respiratory Failure and Intensive Care Support Following Bone Marrow Transplantation.

    Hematology (Amsterdam, Netherlands)·2016
    Same author

    Karyotype differentiation between two stickleback species (Gasterosteidae).

    Cytogenetic and genome research·2011
    Same author

    Polymerase chain reaction based methods for assessing chimerism following allogeneic bone marrow transplantation.

    Methods in molecular medicine·2011
    Same journal

    Mechanisms of resistance to macrophage checkpoint inhibitors in B-cell non-Hodgkin lymphoma for the British Journal of Haematology.

    British journal of haematology·2026
    Same journal

    Advanced fibrosis, TP53 variants and acute/pure erythroid leukaemia: Diagnostic harbingers of ERCC6L2-related bone marrow failure syndrome?

    British journal of haematology·2026
    Same journal

    When macrophages have more than one thing to show.

    British journal of haematology·2026
    Same journal

    Splenic radiotherapy before allogeneic transplantation for myelofibrosis.

    British journal of haematology·2026
    Same journal

    Real-world prevalence and prognostic significance of hepatotoxicity after chimeric antigen receptor T-cell therapy.

    British journal of haematology·2026
    Same journal

    Prognostic impact of germline and somatic variants in lymphoma-associated haemophagocytic lymphohistiocytosis.

    British journal of haematology·2026
    See all related articles

    This study found abnormal T-cell ratios in chronic lymphocytic leukemia (CLL) patients, correlating with disease stage. T-cell proliferation responses to Concanavalin A (Con A) varied by concentration, suggesting a potential role in CLL pathogenesis.

    Area of Science:

    • Hematology
    • Immunology
    • Oncology

    Background:

    • Chronic lymphocytic leukemia (CLL) is a B-cell malignancy.
    • Understanding the role of T-cells in CLL pathogenesis is crucial.

    Purpose of the Study:

    • To investigate T-cell abnormalities in CLL patients.
    • To correlate these abnormalities with clinical staging and disease progression.

    Main Methods:

    • Diagnosis of CLL using clinical findings, blood morphology, and cell surface markers.
    • Rai clinical staging applied to all 15 patients.
    • Evaluation of serum immunoglobins, B-cells, T-cells (TG and TM populations) pre-treatment.
    • Assessment of T-cell proliferation responses to Concanavalin A (Con A) and suppression of allogeneic PBMC responses.

    Related Experiment Videos

    Main Results:

    • No correlation found between clinical stage and hypogammaglobulinaemia.
    • Abnormal T-cell (TG to TM) ratios observed in all patients, paralleling disease stage.
    • Significant differences in T-cell proliferation to Con A at lower concentrations (1-2 µg/ml) compared to controls.
    • T-cell suppression ability was dependent on purification methods.

    Conclusions:

    • T-cell abnormalities, particularly altered TG/TM ratios, are present in CLL and correlate with disease stage.
    • T-cells may play a role in the pathogenesis of chronic lymphocytic leukemia.
    • Further research is needed to elucidate the precise mechanisms of T-cell involvement in CLL.