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Related Experiment Videos

Carcinogenesis studies on guppies.

K Simon, K Lapis

    National Cancer Institute Monograph
    |May 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Guppies (Lebistes reticulatus) are effective models for detecting carcinogenic substances due to their sensitivity. This study identified N,N’-dinitrosopiperazine and two chemotherapy agents as potential carcinogens, highlighting fish as a cost-effective screening alternative.

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    Area of Science:

    • Toxicology
    • Aquatic Animal Models
    • Carcinogenesis Research

    Background:

    • Guppies (Lebistes reticulatus) offer a sensitive and accessible model for toxicological studies.
    • Screening for carcinogenic substances is crucial for environmental and public health.
    • Rodent models are commonly used but can be costly and time-consuming.

    Purpose of the Study:

    • To evaluate the utility of guppies for screening water-soluble carcinogenic substances.
    • To investigate the morphological effects of specific chemicals on guppy livers and gastrointestinal tracts.
    • To identify potential carcinogens among environmental chemicals and chemotherapy candidates.

    Main Methods:

    • Guppies were exposed to known carcinogens (diethylnitrosamine) as positive controls.

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  • Morphological changes in guppy livers and gastrointestinal tracts were analyzed.
  • Ten water-soluble chemicals, including chemotherapy agents and environmental compounds, were tested for carcinogenic effects.

    • Main Results:

    • Diethylnitrosamine induced characteristic liver and gastrointestinal lesions in guppies.
    • N,N'-dinitrosopiperazine, a suspected Triforine derivative, demonstrated carcinogenic effects in guppies.
    • Two of the ten tested chemotherapy agents were identified as potential carcinogens.

    Conclusions:

    • Guppy models provide a cost-effective and rapid method for screening water-soluble carcinogens.
    • The study successfully identified novel carcinogenic effects of specific environmental and therapeutic chemicals.
    • Fish models present a viable alternative to traditional rodent-based carcinogenicity testing.