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Impaired delayed hypersensitivity in lipoid nephrosis
Nephron
|January 1, 1984
Summary
Cell-mediated immunity is impaired in patients with lipoid nephrosis (LN) during the nephrotic stage, as shown by reduced skin test responses. This impairment appears linked to the clinical severity of the disease.
Area of Science:
- Immunology
- Nephrology
Background:
- Cell-mediated immunity (CMI) plays a crucial role in host defense.
- Assessing CMI through delayed cutaneous hypersensitivity (DHS) is vital for understanding immune status in various diseases.
Purpose of the Study:
- To evaluate CMI in patients with renal disease, specifically focusing on lipoid nephrosis (LN).
- To determine if the stage of LN correlates with the degree of immune impairment.
Main Methods:
- Assessed CMI in 76 renal disease patients using DHS skin testing.
- Utilized four antigens: purified protein derivative (PPD), candida, mumps, and keyhole limpet hemocyanin (KLH).
- Compared reactivity in nephrotic LN patients, non-nephrotic LN patients, and healthy controls.
Main Results:
- Patients with LN in the nephrotic stage exhibited reduced skin induration and lower reaction rates to PPD, candida, and mumps compared to controls.
- Immune response to KLH was also diminished in nephrotic LN patients.
- LN patients in remission and those with chronic mesangial proliferative glomerulonephritis (CGN) showed reactivity similar to controls.
Conclusions:
- Lipoid nephrosis is associated with impaired delayed cutaneous hypersensitivity.
- The degree of CMI impairment in LN appears to be related to the clinical stage of the disease.