Influence of lung stretch receptors on the cough reflex in rabbits

The cough reflex in anaesthetized rabbits was elicited by irritation of the larynx with ammonia, inhalation of ammonia into the lungs, and mechanical stimulation of the tracheobronchial tree with a catheter. After block of lung stretch receptors with sulphur dioxide and virtual abolition of the Breuer-Hering inflation reflex, the cough response to all three stimuli was far less frequent and, when it occurred, was weaker especially with respect to the expiratory efforts. It is concluded that the Breuer-Hering reflex enhances the cough reflex, although modification of the sensitivity of tracheobronchial cough and irritant receptors by sulphur dioxide may also influence the cough.