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Related Experiment Videos

Amphotericin B pharmacokinetics in humans.

A J Atkinson, J E Bennett

    Antimicrobial Agents and Chemotherapy
    |February 1, 1978
    PubMed
    Summary

    This study examined amphotericin B pharmacokinetics in patients with disseminated histoplasmosis. The drug exhibits a long elimination half-life of 15 days, indicating slow release from tissues.

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    [Hodgkin's disease demonstrated microscopically in the lymph nodes, prostate, kidney, periadrenal tissue, lung, pancreas, liver, and spleen].

    Gastroenterology·2010

    Area of Science:

    • Pharmacology
    • Mycology
    • Infectious Diseases

    Background:

    • Disseminated histoplasmosis requires long-term antifungal therapy.
    • Amphotericin B is a critical antifungal agent, but its pharmacokinetic profile requires further elucidation.

    Purpose of the Study:

    • To characterize the pharmacokinetics of amphotericin B in patients completing long-term therapy for disseminated histoplasmosis.
    • To develop a pharmacokinetic model for amphotericin B to simulate different dosing regimens.

    Main Methods:

    • Pharmacokinetic analysis of amphotericin B in two patients.
    • Utilized a three-compartment mamillary model to describe drug distribution.
    • Simulated serum levels based on different initial therapeutic regimens.

    Main Results:

    • Amphotericin B distribution volume averaged 4 L/kg.
    • Elimination half-life was approximately 15 days, suggesting slow peripheral release.
    • Renal excretion represented only 3% of total drug elimination.

    Conclusions:

    • Amphotericin B exhibits prolonged elimination due to slow release from tissues.
    • The developed pharmacokinetic model can inform optimal dosing strategies for histoplasmosis treatment.

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