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Related Experiment Videos

Migraine and systemic scleroderma.

N C Goldberg, S C Duncan, R K Winkelmann

    Archives of Dermatology
    |April 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Long-term use of ergot or methysergide for migraines may be linked to scleroderma development. Patients on these therapies, especially those with Raynaud's phenomenon, require careful monitoring for early vascular scleroderma signs.

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    Area of Science:

    • Rheumatology
    • Neurology
    • Vascular Medicine

    Background:

    • Scleroderma and migraine headaches are distinct conditions.
    • Ergot and methysergide are commonly prescribed for migraine treatment.

    Purpose of the Study:

    • To investigate a potential association between long-term ergot/methysergide therapy and the development of scleroderma in migraine patients.

    Main Methods:

    • Retrospective case review of 16 patients with scleroderma and migraine headaches over 25 years.
    • Analysis of medication history, focusing on ergot or methysergide use duration.

    Main Results:

    • Scleroderma developed in 13 of 16 patients after 15+ years of ergot/methysergide therapy.
    • Eleven of these 13 patients also exhibited Raynaud's phenomenon.

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  • Vascular pathology in scleroderma, Raynaud's, and ergotism shows similarities.

    • Conclusions:

    • Prolonged ergot/methysergide use may increase scleroderma risk in migraineurs.
    • Caution advised when prescribing these drugs to migraine patients.
    • Vigilant monitoring for Raynaud's phenomenon and early vascular scleroderma is crucial.