Effect of pindolol, a beta-adrenoceptor blocking agent, on lipid metabolism

Pindolol, a beta-adrenoceptor blocking agent, was administered to rats to determine the effects of the drug on lipid and lipoprotein in plasma and tissues. The drug caused significant reductions in plasma triglyceride, free fatty acid and very low density lipoprotein. As for lipoprotein lipase activity, the drug produced varying effects; an increase in the heart and a reduction in the adipose tissue. No significant changes in plasma cholesterol, low density lipoprotein and high density lipoprotein cholesterol were observed. The disturbance of growth was noted following pindolol treatment.