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Related Experiment Videos

Phenthoate toxicity: cumulative effects in rats.

P K Gupta

    Toxicology Letters
    |July 1, 1984
    PubMed
    Summary

    This study investigated the cumulative toxicity of phenthoate, an organophosphorus insecticide, in male rats. Phenthoate was found to be moderately hazardous, with cumulative toxicity observed after prolonged exposure.

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    Area of Science:

    • Toxicology
    • Environmental Science
    • Animal Studies

    Background:

    • Organophosphorus insecticides are widely used in agriculture.
    • Understanding the cumulative effects of pesticides is crucial for risk assessment.
    • Phenthoate is an insecticide whose chronic toxicity requires thorough investigation.

    Purpose of the Study:

    • To determine the cumulative toxicity of phenthoate in male rats.
    • To establish the cumulative LD50 (CLD50) for phenthoate.
    • To assess the impact of phenthoate exposure on organ weights and animal survival.

    Main Methods:

    • Male rats were administered phenthoate orally for a minimum of 10 weeks.
    • Dosing continued until the CLD50 remained constant for three consecutive weeks.
    • Organ weights and animal survival rates were monitored at various dose levels.

    Main Results:

    • The oral LD50 of phenthoate varied depending on the vehicle, with groundnut oil showing the highest value (116 mg/kg).
    • Lower body weight correlated with increased susceptibility to phenthoate toxicity.
    • Exposure to 2.5-10 mg/kg phenthoate for 13 weeks resulted in decreased organ weights, while 40 mg/kg was lethal.
    • The 13-week CLD50 was determined to be 12 mg/kg, with a cumulative toxicity factor of 6.3.

    Conclusions:

    • Phenthoate exhibits cumulative toxicity in male rats.
    • The compound is classified as moderately hazardous based on the observed effects.
    • Findings highlight the importance of considering cumulative exposure in pesticide risk assessments.

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