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[Effect on hemostasis and thrombogenesis by septic processes especially in childhood]
Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|May 15, 1984
Summary
Pediatric sepsis involves complex coagulation changes. Coagulation factors initially decrease then normalize, while acute phase proteins rise, indicating disseminated intravascular coagulation and diagnostic potential.
Area of Science:
- Pediatric Hematology
- Critical Care Medicine
- Coagulation Science
Background:
- Sepsis in children presents diverse coagulation abnormalities.
- Understanding these dynamics is crucial for diagnosis and management.
Purpose of the Study:
- To analyze coagulation factor dynamics in pediatric sepsis.
- To differentiate sepsis in neonatal versus non-neonatal periods.
- To assess the diagnostic value of coagulation parameters.
Main Methods:
- Coagulation analyses performed on 284 children with sepsis.
- Monitoring of thrombocytes, plasminogen, antithrombin III, alpha 2-macroglobulin, factor V, fibrinogen, alpha 2-antiplasmin, factors II and X, and trypsin inhibitor capacity.
- Comparison of coagulation profiles between neonatal and non-neonatal sepsis.
Main Results:
- Neonatal sepsis: initial decrease in thrombocytes and certain factors, increase in fibrinogen and acute phase proteins; prolonged thrombocytopenia.
- Non-neonatal sepsis: more pronounced acute phase protein response, variable thrombocytopenia often with thrombocytosis.
- Observed dynamics suggest frequent disseminated intravascular coagulation (DIC) and compensatory overproduction of coagulation components.
Conclusions:
- Coagulation parameter dynamics in pediatric sepsis have significant diagnostic value.
- DIC is a common complication in early sepsis, influencing coagulation profiles.
- Differences in coagulation dynamics exist between neonatal and non-neonatal sepsis.