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Updated: Aug 18, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
[Various aspects of the biological basis for rehabilitating epileptics]
Abstract:
Using the clinical data on 270 epileptic patients, the author offers the biological validation of occupational treatment, determines the role of the psychological effects in the system of patients' rehabilitation and validates the significance of the EEG as a method for objective assessment of the degree of the regression of the clinical and subclinical manifestations of epilepsy in the process of biological therapy. It has been established that: 1) psychosocial effects, in particular, the patients' occupational activity help to decrease the frequency of attacks and inhibit the paroxysmal activity on the EEG during an experiment simulating a working process; 2) a long-term (up to 8 years) absence of seizures according to the EEG readings is not always attended with the regression of the subclinical manifestations of epilepsy; 3) the realization of rehabilitation programmes should be evaluated, appart from the duration of the attack-free period, by the EEG readings as well.

