Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Staging laparotomy in Hodgkin's disease.

W R Sandusky, R C Jones, J S Horsley

    Annals of Surgery
    |May 1, 1978
    PubMed
    Summary

    Staging laparotomy accurately stages Hodgkin's disease, altering therapy for 38% of patients. This procedure, including biopsies and splenectomy, revealed unexpected intra-abdominal involvement in 21% of cases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Some Observations on the Use of Apomorphine.

    Atlanta journal-record of medicine·2022
    Same author

    A hospital outbreak of an NDM-producing ST167 Escherichia coli with a possible link to a toilet.

    The Journal of hospital infection·2021
    Same author

    Pentothal Sodium in Mental Hospital Practice.

    British medical journal·2010
    Same author

    Motor neuron disease and serum monoclonal proteins: poor response to treatment of the paraproteinemia.

    Journal of clinical neuromuscular disease·2008
    Same author

    Fluid and electrolyte reabsorption in the ductuli efferentes testis.

    Journal of reproduction and fertility. Supplement·2000
    Same author

    pH and bicarbonate in the ductuli efferentes testis of the rat.

    International journal of andrology·2000

    Area of Science:

    • Oncology
    • Surgical Pathology
    • Diagnostic Imaging

    Background:

    • Hodgkin's disease staging is crucial for treatment planning.
    • Accurate staging impacts therapeutic decisions and patient outcomes.
    • Limitations of clinical staging necessitate surgical exploration.

    Purpose of the Study:

    • To evaluate the impact of staging laparotomy on the pathological staging and subsequent therapy in patients with Hodgkin's disease.
    • To assess the accuracy of lymphangiography compared to histopathological findings.
    • To determine the incidence of splenic involvement and its preoperative predictability.

    Main Methods:

    • Staging laparotomy with liver and lymph node biopsies, and splenectomy in 111 Hodgkin's disease patients.
    • Histopathological review for disease classification and staging.

    Related Experiment Videos

  • Correlation of lymphangiography results with surgical findings.

    • Main Results:

    • Pathologic stage (PS) changed from clinical stage (CS) in 36% of patients (reduced in 20%, advanced in 16%).
    • Therapy was altered in 38% of patients based on laparotomy findings.
    • Lymphangiography showed 77% accuracy, with 21% false positives; splenic involvement was found in 39% of cases, often unsuspected preoperatively.

    Conclusions:

    • Staging laparotomy is essential for accurate Hodgkin's disease staging and therapeutic modification.
    • Lymphangiography has moderate accuracy, with a significant false-positive rate.
    • Splenic involvement is common and frequently underestimated by clinical evaluation.