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Myocardial perfusion abnormalities in asymptomatic patients with systemic lupus erythematosus

J D Hosenpud, A Montanaro, M V Hart

    The American Journal of Medicine
    |August 1, 1984
    PubMed

    Insights

    Systemic lupus erythematosus (SLE) patients frequently show myocardial perfusion abnormalities, indicating potential heart issues. A history of pericarditis was linked to these findings in a study of SLE patients.

    Area of Science:

    • Cardiology
    • Rheumatology
    • Nuclear Medicine

    Background:

    • Accelerated coronary artery disease and myocardial infarction are known risks in young patients with systemic lupus erythematosus (SLE).
    • The prevalence of coronary involvement in SLE patients remains largely undetermined.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of coronary involvement in patients with SLE.
    • To assess myocardial perfusion using exercise thallium-201 cardiac scintigraphy in SLE patients without prior cardiac history.

    Main Methods:

    • Exercise thallium-201 cardiac scintigraphy was performed on 26 SLE patients.
    • Patients were selected irrespective of their previous cardiac history.

    Main Results:

    • Segmental myocardial perfusion abnormalities were detected in 38.5% (10 of 26) of SLE patients.
    • Abnormalities included reversible defects (ischemia) in 5 patients and persistent defects (scar) in 4 patients.
    • No correlation was found between positive thallium results and disease duration, corticosteroid use, organ involvement, or age; however, a history of pericarditis was associated with positive results (p < 0.05).

    Conclusions:

    • Segmental myocardial perfusion abnormalities are common in patients with systemic lupus erythematosus.
    • The underlying cause of these abnormalities (large-vessel coronary disease vs. small-vessel disease) requires further investigation.

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