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Two case reports of trazodone-induced mania
The American Journal of Psychiatry
|September 1, 1984
Summary
Trazodone, an antidepressant, may trigger manic symptoms in some patients with unipolar depression. These symptoms subsided after discontinuing the medication, marking a potentially new adverse effect.
Area of Science:
- Psychiatry
- Pharmacology
- Neuroscience
Background:
- Unipolar depression is a common mood disorder.
- Antidepressant medications are standard treatments.
- Trazodone is a commonly prescribed antidepressant.
Observation:
- Two patients with unipolar depression experienced manic symptoms during trazodone treatment.
- The manic symptoms resolved upon cessation of trazodone.
Findings:
- This study reports the first two documented cases of trazodone-induced mania in unipolar depression.
- The findings suggest a potential link between trazodone and manic switch.
Implications:
- Clinicians should be aware of this potential adverse effect when prescribing trazodone.
- Further research is warranted to understand the mechanism of trazodone-induced mania.
- This highlights the importance of careful patient monitoring during antidepressant therapy.