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Related Experiment Videos

Halothane and children: the first quarter century.

L O Warner, T P Beach, J P Garvin

    Anesthesia and Analgesia
    |September 1, 1984
    PubMed
    Summary

    Halothane anesthesia is rarely problematic for children, with few serious side effects reported in over 200,000 cases. Most adverse reactions were manageable, and no deaths or permanent issues occurred.

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    Area of Science:

    • Anesthesiology
    • Pediatric Anesthesia
    • Pharmacovigilance

    Background:

    • Halothane has been the primary anesthetic at Children's Hospital, Columbus, Ohio for 25 years.
    • Previous observations suggested rare adverse reactions to halothane in pediatric patients.

    Purpose of the Study:

    • To confirm the impression of rare adverse reactions to halothane in children.
    • To evaluate the safety profile of halothane in a large pediatric cohort.

    Main Methods:

    • Retrospective review of 200,311 cases using halothane.
    • Analysis of life-threatening complications and potential contributing factors.

    Main Results:

    • Fifteen patients experienced life-threatening complications: hepatitis (1), malignant hyperthermia (10), and cardiac arrhythmias (4).
    • No deaths or permanent sequelae were reported in any child.
    • Eleven cases involved possible contributions from other drugs like succinylcholine, atropine, cocaine, and epinephrine.

    Conclusions:

    • Halothane appears to be a safe anesthetic agent for pediatric use with a low incidence of severe adverse events.
    • Malignant hyperthermia was the most frequent serious complication associated with halothane anesthesia in this cohort.
    • Concurrent administration of other drugs may increase the risk of adverse reactions during halothane anesthesia.

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