Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis associated with high-dose oxacillin therapy.

A A Pollock, S A Berger, M S Simberkoff

    Archives of Internal Medicine
    |June 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Elevated calpain activity in acute myelogenous leukemia correlates with decreased calpastatin expression.

    Blood cancer journal·2012
    Same author

    RAxML-Light: a tool for computing terabyte phylogenies.

    Bioinformatics (Oxford, England)·2012
    Same author

    AID and RAG1 do not contribute to lymphomagenesis in Emu c-myc transgenic mice.

    Oncogene·2008
    Same author

    Sickle cell blood flow in the microcirculation.

    Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
    Same author

    Polymyxin B-Resistant Acinetobacter baumannii Clinical Isolate Susceptible to Recombinant BPI and Cecropin P1.

    Antimicrobial agents and chemotherapy·2006
    Same author

    Acinetobacter.

    Seminars in respiratory and critical care medicine·2005
    Same journal

    Elevated CK-MB With Normal Total Creatine Kinase Levels in Patients Undergoing Maintenance Hemodialysis-Reply.

    Archives of internal medicine·2017
    Same journal

    Occult Carbon Monoxide Poisoning-Reply.

    Archives of internal medicine·2017
    Same journal

    Acquired Immune Deficiency Syndrome-Reply.

    Archives of internal medicine·2017
    Same journal

    Heparin Side Effects-Reply.

    Archives of internal medicine·2017
    Same journal

    Humanizing primary care medicine begins with stress.

    Archives of internal medicine·2017
    Same journal

    Legend omitted and number misrepresented.

    Archives of internal medicine·2013
    See all related articles

    Oxacillin sodium therapy can cause liver abnormalities, including elevated transaminase levels, in some patients. These drug-related liver issues were reversible upon discontinuing oxacillin.

    Area of Science:

    • Pharmacology
    • Hepatology
    • Infectious Diseases

    Background:

    • Oxacillin sodium is an antibiotic commonly used to treat bacterial infections.
    • Liver function abnormalities are potential adverse effects of various medications.

    Purpose of the Study:

    • To investigate the incidence and characteristics of liver function abnormalities associated with oxacillin sodium therapy.
    • To identify risk factors for drug-related hepatic dysfunction during oxacillin treatment.

    Main Methods:

    • A prospective survey was conducted on 41 patients receiving oxacillin sodium.
    • Liver function tests, including serum transaminases, alkaline phosphatase, and bilirubin, were monitored.

    Main Results:

    • Five out of 41 patients (12.2%) developed drug-related liver abnormalities.

    Related Experiment Videos

  • Abnormalities included elevated serum transaminases (>100 units) with mild alkaline phosphatase increases; bilirubin remained normal.
  • Asymptomatic hepatic dysfunction was reversible upon oxacillin withdrawal and antibiotic substitution (cephalosporin or clindamycin).
  • Risk factors identified included high-dose oxacillin sodium (≥12 gm/day), heroin addiction, and staphylococcal endocarditis.

    • Conclusions:

    • Oxacillin sodium can induce asymptomatic, reversible liver function abnormalities in a subset of patients.
    • High-dose oxacillin, heroin addiction, and staphylococcal endocarditis are associated with increased risk.
    • Monitoring liver function is advisable in patients receiving high-dose oxacillin, particularly those with risk factors.