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Related Experiment Videos

Sickle cell blood flow in the microcirculation.

S A Berger1, B E Carlson

  • 1Department of Bioengineering, California University, Berkeley, CA, USA.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 3, 2007
PubMed
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Sickle-cell disease causes capillary issues due to deoxygenated red blood cells. Microcirculation models suggest blood pressure may control sickle-cell red blood cell flow.

Area of Science:

  • Hematology
  • Biophysics
  • Medical modeling

Background:

  • Sickle-cell disease (SCD) involves abnormal red blood cells (RBCs) that cause capillary complications.
  • Deoxygenation triggers rheological changes in sickle-cell erythrocytes, leading to clinical symptoms and subclinical sequelae.
  • SCD crises are episodic, painful events linked to microcirculatory dysfunction.

Purpose of the Study:

  • To model the flow of sickle-cell erythrocytes in capillaries and microcirculatory beds.
  • To investigate the underlying mechanisms of sickle-cell disease pathophysiology.
  • To identify potential control parameters in sickle-cell disease microcirculation.

Main Methods:

  • Development of a computational model for RBC flow in a single capillary, incorporating SCD characteristics.

Related Experiment Videos

  • Extension of the single-capillary model to a pseudo-randomly generated microcirculatory bed.
  • Analysis of rheological changes in deoxygenated sickle-cell erythrocytes.

    • Main Results:

    • The model simulates RBC flow dynamics under deoxygenated conditions.
    • Simulations reveal potential for abnormal flow events in sickle-cell disease capillaries.
    • Microcirculatory modeling suggests pressure as a key parameter influencing RBC transit.

    Conclusions:

    • Abnormal capillary events are central to sickle-cell disease symptomology.
    • Microcirculatory modeling provides insights into SCD pathophysiology.
    • Blood pressure may be a critical factor regulating sickle-cell red blood cell flow in the microcirculation.