Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular transformation phenomenon in human malignant melanomas.

H Klug

    Archiv Fur Geschwulstforschung
    |January 1, 1984
    PubMed
    Summary

    Human melanoma cells undergo a striking cellular transformation, exhibiting enlarged nuclei and abundant melanosomes. This phenomenon, observed via electron microscopy, suggests potential transfer of nuclear substances to neighboring keratinocytes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Influence of the autonomic nervous system on hemopoiesis].

    Acta neurovegetativa·2014
    Same author

    The opportunity to be misled in studies of sexual selection.

    Journal of evolutionary biology·2012
    Same author

    Effects of among-offspring relatedness on the origins and evolution of parental care and filial cannibalism.

    Journal of evolutionary biology·2011
    Same author

    The evolution of parental care in stochastic environments.

    Journal of evolutionary biology·2011
    Same author

    The mismeasurement of sexual selection.

    Journal of evolutionary biology·2010
    Same author

    Detachment factors for enhanced carrier to carrier transfer of CHO cell lines on macroporous microcarriers.

    Cytotechnology·2008

    Area of Science:

    • Dermatology
    • Cell Biology
    • Oncology

    Background:

    • Human cutaneous malignant melanoma exhibits complex cellular changes.
    • Understanding keratinocyte transformation is crucial for melanoma research.

    Purpose of the Study:

    • To describe the cellular transformation phenomenon in keratinocytes during human cutaneous malignant melanoma.
    • To compare these transformations with those in lentigo maligna.

    Main Methods:

    • Electron microscopic studies of human cutaneous malignant melanoma.
    • Histologic examination of cellular and subcellular changes.

    Main Results:

    • Observed striking nuclear enlargement, nucleolar changes, and chromatin alterations in keratinocytes.
    • Noted cytoplasmic changes including desmosome degradation and increased mitochondria.
    • Identified numerous melanosomes, making transformed cells ultrastructurally similar to true tumor cells.

    Conclusions:

    • Human cutaneous malignant melanoma involves a distinct keratinocyte transformation.
    • Potential transfer of nuclear substances to adjacent keratinocytes may occur.
    • Minimal similar reactions were seen in lentigo maligna, highlighting melanoma's unique cellular dynamics.

    Related Experiment Videos