[Morphology and morphogenesis of recurrent experimental myocardial infarct]

The results of morphological investigations of relapsing myocardial infarction in 148 rabbits are presented. In most cases the relapses occurred spontaneously at intervals of several to 45 days after reproduction of the primary myocardial infarction by high ligation of the anterior interventricle artery of the heart. It was found that relapses of myocardial infarction could develop in animals normal before the experiment (I series), against the background of cholesterol atherosclerosis (II series), renal hypertension (III series) and particularly frequently in combinations of cholesterol atherosclerosis and renal hypertension (IV series) as well as after repeated delayed ligation of the anterior interventricle artery (V series). The relapses occurred early in primary infarction and in the period of its scarring. The regularities of mutual location of foci of primary infarction and relapses, the frequency and number of their occurrences, location and size were investigated.