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Related Experiment Videos

Hepatitis B surface antigen in human tears.

R W Darrell, G B Jacob

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |April 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Hepatitis B virus (HBV) is increasingly transmitted among healthcare workers. This study found hepatitis B surface antigen in tears, indicating a risk via contaminated medical equipment like tonometers and contact lenses.

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    Area of Science:

    • Virology
    • Infectious Diseases
    • Ophthalmology

    Background:

    • Hepatitis B virus (HBV) infection incidence is rising in the US, especially among healthcare professionals.
    • Transmission routes beyond blood exposure, including respiratory, fecal-oral, and venereal, are suggested by epidemiological data.
    • Hepatitis B surface antigen (HBsAg) has been detected in various body secretions, hinting at broader transmission possibilities.

    Purpose of the Study:

    • To investigate the presence of hepatitis B surface antigen (HBsAg) in the tears of infected individuals.
    • To assess the potential for HBV transmission through ocular exposure or contaminated ophthalmic instruments.

    Main Methods:

    • Tears were collected from patients with confirmed HBsAg-positive serum.
    • Collected tear samples were tested for the presence of HBsAg using appropriate diagnostic methods.

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    Main Results:

    • Hepatitis B surface antigen (HBsAg) was detected in tears from 50% of the HBsAg-positive patients studied.
    • This finding supports the presence of HBV in ocular secretions.

    Conclusions:

    • Tears can be a potential source of hepatitis B virus transmission.
    • There is a demonstrable risk of transmitting HBV through contaminated tonometers or soft contact lenses.
    • Ocular secretions should be considered in the context of HBV transmission, particularly in healthcare settings.